camp receptors การใช้

• There are also several sets of repeats, sequences resembling the Sp1 transcription factor binding site, and two cAMP receptor binding sites upstream of the cap.
• They are believed to have evolved from the cAMP receptor family, arising approximately 1275 million years ago before the split of Unikonts from a common ancestor.
• In an environment with a low glucose concentration, cAMP accumulates and binds to the allosteric site on CRP ( cAMP receptor protein ), a transcription activator protein.
• First discovered in Gram-negative bacteria, both Cyclic AMP ( cAMP ) and cAMP Receptor Protein ( CRP ) function in sucrose phosphorylase regulation ( Reid and Abratt 2005 ).
• However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity between these families : the cAMP receptors thus bear their own unique'7TM'signature.
• While growing on media in which growth rates are low, cAMP binds to a cAMP Receptor Protein ( CRP ) forming a "'CRP-cAMP complex "'which has regulatory properties.
• The " malEp " and " malKp " promoters are synergistically activated by protein MalT, the activator of the Mal regulon and by the cAMP receptor protein CRP . This activation is a coupled process that involves, going from " malEp " towards " malKp " : two MalT binding sites; three CRP binding site, and two overlapping sets of three MalT binding sites, staggered by three base pairs.